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KMID : 0882420080750000913
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Korean Journal of Medicine
2008 Volume.75 No. 0 p.913 ~ p.916
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A case of pure red cell aplasia associated with parvovirus B19 infection in an AIDS patient
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Lee Jae-Hoon
Kim Eui-Chong
Oh Myoung-Don
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Abstract
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Persistent infection with parvovirus B19 is an important treatable cause of anemia in HIV-infected patients. The failure to produce neutralizing antibodies to parvovirus B19 may result in persistent viremia and chronic pure red cell aplasia (PRCA) in immunodeficient patients. We report a case of parvovirus B19-related PRCA in an AIDS patient. The patient was a 39-year-old male who was confirmed to have HIV infection 4 years earlier. He developed a normocytic anemia 5 months ago (hemoglobin 9.9 g/dL), which worsened slowly. He complained of exertional dyspnea and required a blood transfusion. At admission, his hemoglobin was 4.6 g/dL. The bone marrow examination was consistent with PRCA and positive for parvovirus B19 DNA using the polymerase chain reaction. He was given intravenous immunoglobulin (IVIG) 400 mg/kg for 5 days and his anemia improved. He has been observed without relapse for 3 months. (Korean J Med 75:S913-S916, 2008)
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KEYWORD
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HIV, Parvovirus, Red cell aplasia
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